Here are the highlights:
"A surefooted screen translation of Michael Chabon's beloved 1988 debut novel, "The Mysteries of Pittsburgh" will likely irk diehard fans of the book, as helmer-adaptor Rawson Marshall Thurber takes considerable liberties and arrives at a more conventional general tone."
and... "The full warmth and idiosyncrasy of Chabon's original is missed in an adaptation that feels more impersonally observed."
Unfortunately, the rest isn't as bad and predicts it will do well with straight/gay audiences between 20s-40s.
http://www.variety.com/review/VE1117935891.html?categoryid=31&cs=1&nid=2562